Synthesis of 14C‐labelled heterocyclic analogues of phenylalanine with pyrazole and furan rings
作者:
V. Tolman,
J. Hanuš,
K. Vereš,
期刊:
Journal of Labelled Compounds
(WILEY Available online 1968)
卷期:
Volume 4,
issue 3
页码: 243-247
ISSN:0022-2135
年代: 1968
DOI:10.1002/jlcr.2590040307
出版商: John Wiley&Sons, Ltd.
数据来源: WILEY
摘要:
AbstractDiethyl acetamidomalonate‐2‐14C was alkylated by l‐chloromethylpyrazole and the reaction intermediate hydrolyzed to give DL‐3‐(1′‐pyrazolyl)‐alanine‐2‐14C. By the same method, but using 3‐chloromethylpyrazole instead of the 1‐isomer, DL‐3‐(3′‐pyrazolyl)‐alanine‐2‐14C was prepared. Condensation of furfural with hydantoin‐5‐14C gave 5‐(2′‐furylidene)‐hydantoin‐5‐14C, which was subsequently reduced to 5‐(2′‐furyl)‐hydantoin‐5‐14C and this compound was hydrolyzed to DL‐3‐(2′‐furyl)‐alanine‐2‐14C. Methods f
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