Renal function in sick, very low‐birth‐weight infants
作者:
M Vanpée,
U Ergander,
P Herin,
A Aperia,
期刊:
Acta Paediatrica
(WILEY Available online 1993)
卷期:
Volume 82,
issue 9
页码: 714-718
ISSN:0803-5253
年代: 1993
DOI:10.1111/j.1651-2227.1993.tb12544.x
出版商: Blackwell Publishing Ltd
关键词: Creatinine clearance;mechanical ventilation;patent ductus arteriosus;renal function;very low‐birth‐weight infants
数据来源: WILEY
摘要:
Renal immaturity is pronounced in very low‐birth‐weight infants with a gestational age 30 weeks. We attempted to elucidate if conditions requiring mechanical ventilation, including patent ductus arteriosus, might further compromise renal function due to decreased renal perfusion. Forty infants studied between 4 and 28 days of age were divided into four groups: Control with no patent ductus or mechanical ventilation (n= 8); PDA + MV, with both patent ductus and mechanical ventilation (n=17); PDA, with patent ductus (n= 6); MV, with mechanical ventilation (n= 9). The groups PDA + MV and MV had significantly lower creatinine clearances and significantly higher fractional sodium excretions than controls. Mean arterial pressure was significantly lower in all groups compared to controls and correlated significantly with creatinine clearance (r = 0.47, p<0.02). In conclusion, low renal function in these infants is further compromised by a patent ductus arteriosus and/or the use of mechanical ventilat
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