Role of macrophage‐processed antigen in a Plasmodium berghei model
作者:
ARUNA PARASHAR,
S. SEHGAL,
S. NAIK,
B.K. AIKAT,
期刊:
Parasite Immunology
(WILEY Available online 1983)
卷期:
Volume 5,
issue 2
页码: 173-181
ISSN:0141-9838
年代: 1983
DOI:10.1111/j.1365-3024.1983.tb00735.x
出版商: Blackwell Publishing Ltd
关键词: Plasmodium berghei;macrophage;malaria
数据来源: WILEY
摘要:
SummaryThe present study demonstrates that malarial parasite could be processed by macrophages in vitro to release ‘super antigens’. These super antigens obtained from the peritoneal macrophages were more protective than those processed by the splenic adherent cells. BCG‐stimulated macrophages were also able to process the antigens efficiently and these antigens were even superior to those obtained from the unstimulated macrophages. These modified antigens were potent inducers of DFPS to malarial antigens. It is thus concluded that parasite antigens, processed in vitro, carry specific immunogenic potential and are able to protect the recipients to parasite chal
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