Myoepithelium in Salivary and Mammary Neoplasms is Host-Friendly
作者:
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期刊:
Advances in Anatomic Pathology
(OVID Available online 1999)
卷期:
Volume 6,
issue 4
页码: 218-226
ISSN:1072-4109
年代: 1999
出版商: OVID
关键词: Myoepithelium;Breast neoplasms;Salivary gland neoplasms;Adenoid cystic carcinoma;Epithelial-myoepithelial carcinoma;Adenomyoepithelioma
数据来源: OVID
摘要:
Summary:This commentary relates to ameliorative effects of myoepithelial cells in carcinomas of salivary glands and the breast as viewed not only by proliferative characteristics, but also by laboratory experiments and clinicopathologic evidence. The tumor suppressor action of myoepithelium is, in part, associated with its matrix-synthesizing and proteinase inhibitor properties. Loss of the myoepithelial phenotype yields a more aggressive carcinoma with enhanced invasive and metastatic capability.
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