Effects of Acute and Chronic Digoxin Administration in Dogs with Right‐Sided Congestive Heart Failure Produced by Pulmonary Artery Constriction
作者:
James Davis,
David Howell,
Robert Hyatt,
期刊:
Circulation Research
(OVID Available online 1955)
卷期:
Volume 3,
issue 3
页码: 259-263
ISSN:0009-7330
年代: 1955
出版商: OVID
数据来源: OVID
摘要:
Acute and chronic responses to digoxin have been studied in dogs with cardiac failure secondary to constriction of the pulmonary artery. Cardiovascular and renal hemodynamic function improved and, frequently, a striking increase in sodium (Na) excretion resulted. The data suggest a direct myocardial action of digoxin and provide evidence of impaired myocardial function similar to that observed in patients with congestive heart failure.
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