Distribution of Myosin, Actin and Actin-Binding Protein in Thrombasthenic Platelets
作者:
Amiram Eldor,
Itzhak Kahane,
Andras Muhlrad,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1980)
卷期:
Volume 9,
issue 1
页码: 28-35
ISSN:1424-8832
年代: 1980
DOI:10.1159/000214338
出版商: S. Karger AG
关键词: Platelets;Thrombasthenia;Myosin;Actin;Actin-binding protein
数据来源: Karger
摘要:
The quantity of myosin, actin, and actin-binding protein (ABP) in platelets and platelet fractions of 5 patients with Glanzmann’s thrombasthenia were compared to those of normal individuals. No significant differences were observed between the average amounts of these contractile proteins in unfractionated platelets or platelet membrane obtained after osmotic shock. However, the amount of myosin was significantly decreased in the KC1 extract of thrombasthenic platelets ruptured by freezing and thawing, while its specific ATPase activity was increase
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