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Distribution of Myosin, Actin and Actin-Binding Protein in Thrombasthenic Platelets

 

作者: Amiram Eldor,   Itzhak Kahane,   Andras Muhlrad,  

 

期刊: Pathophysiology of Haemostasis and Thrombosis  (Karger Available online 1980)
卷期: Volume 9, issue 1  

页码: 28-35

 

ISSN:1424-8832

 

年代: 1980

 

DOI:10.1159/000214338

 

出版商: S. Karger AG

 

关键词: Platelets;Thrombasthenia;Myosin;Actin;Actin-binding protein

 

数据来源: Karger

 

摘要:

The quantity of myosin, actin, and actin-binding protein (ABP) in platelets and platelet fractions of 5 patients with Glanzmann’s thrombasthenia were compared to those of normal individuals. No significant differences were observed between the average amounts of these contractile proteins in unfractionated platelets or platelet membrane obtained after osmotic shock. However, the amount of myosin was significantly decreased in the KC1 extract of thrombasthenic platelets ruptured by freezing and thawing, while its specific ATPase activity was increase

 

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