Outward Transcutaneous Chemical Migration: Implications for Diagnostics and Dosimetry
作者:
Carl C. Peck,
Dale P. Conner,
Brenda J. Bolden,
Ramona G. Almirez,
Thomas E. Kingsley,
Leroy D. Mell,
Gail Murphy,
Vincent E. Hill,
Laura M. Rowland,
David Ezra,
Terease E. Kwiatkowski,
Charles R. Bradley,
Maged Abdel-Rahim,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1988)
卷期:
Volume 1,
issue 1
页码: 14-23
ISSN:1660-5527
年代: 1988
DOI:10.1159/000210747
出版商: S. Karger AG
关键词: Outward transcutaneous chemical migration;Reverse transdermal drug delivery;Diffusion;Dosimetry;Permeability coefficient, noninvasive, in vivo
数据来源: Karger
摘要:
Chemical substances migrate outwards from within the body to the skin surface by diffusion from cutaneous capillaries across the epidermis. Heretofore, study of transepidermal chemical emissions have been restricted to substances which are in the vapor phase at skin surface temperature. We have investigated outward transcutaneous chemical migration of nongaseous chemicals by devising an occlusive transcutaneous chemical collection system, consisting of a tape-encased plug of gelled saline in which activated carbon is dispersed. Investigations of nine chemicals in ‘fuzzy’ rats, rhesus monkeys, and man provide data which are consistent with a general theory of outward transcutaneous chemical migration. This noninvasive continuous transcutaneous sampling technique provides a new method for investigating skin permeability in vivo and may provide a basis for convenient diagnosis and monitoring of chemical exposure.
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