A 2½-year-old wire-haired fox terrier had a 2-month history of inappetance, gagging, retching, regurgitation and vomiting associated with bilateral necrosis of the mandibular salivary glands. Surgical removal of the glands did not greatly improve the demeanor of the dog, or alleviate the regurgitation and vomiting. Euthanasia was recommended because of the failure to respond to supportive therapy. The affected glands were enlarged and showed infarction with peripheral reactive inflammation. Compensatory hypertrophy and hyperplasia of the parotid salivary glands were the only other significant pathological findings. No explanation for the vomiting could be found.