Antiviral activity of certain hetarylhydrazones in Mengo virus infected mice
作者:
Anneliese Veckenstedt,
H. Ulbricht,
期刊:
Zeitschrift für allgemeine Mikrobiologie
(WILEY Available online 1977)
卷期:
Volume 17,
issue 1
页码: 69-74
ISSN:0044-2208
年代: 1977
DOI:10.1002/jobm.19770170109
出版商: Akademie‐Verlag
数据来源: WILEY
摘要:
AbstractOut of a series of eleven related hetarylhydrazones four derivatives (ZIMET 124/73, ZIMET 38/74, ZIMET 44/69, and IMET 98/69), after subcutaneous administration (0.5 mmole/kg per injection), were found to possess significant antiviral activity against rapidly progressing and highly lethal Mengo virus encephalitis in mice. After peroral administration (2 mmole/kg per injection) only with IMET 98/69 significant protection was achieved. Drug treatments were given twice daily for 5 days. The effectiveness of compounds was evidenced by significant „rates of protection”︁. Possible relationships between the antiviral activity and the structure of compounds are disc
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