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Antitumour Activity of Some Platinum Compounds

 

作者: Bimal K. Chakraborty,   Nupur Biswas,   Kanakendu Choudhury,   Rajat.K. Neogy,   Das Sarma,  

 

期刊: Chemotherapy  （Karger Available online 1985）
卷期: Volume 31, issue 1  

页码: 55-59

 

ISSN:0009-3157

 

年代: 1985

 

DOI:10.1159/000238314

 

出版商: S. Karger AG

 

关键词: Cancer chemotherapy;Cis-platinum;Drug-DNA complex

 

数据来源: Karger

 

摘要:

A group of cis-ethylenediammine platinum(II) complexes were synthesized and their activity against Sarcoma-180 ascites tumour cells in mouse was tested. One of the compounds, Pt(HOCH2CH2NHCH2CH2NH2)Cl2, showed significant antitumour activity having little toxicity to the host. Like the parent compound, cis-DDP, it binds to DNA, but transcription is not the primary process inhibited by these compounds. The drug-DNA complex, though less toxic, was not more effective than the free drug.

 

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