Involvement of Arachidonate-Dependent Lipid Mediators and Platelet-Activating Factor in Experimental Murine Contact Dermatitis
作者:
M. Csatò,
T. Rosenbach,
B.M. Czarnetzki,
期刊:
Skin Pharmacology and Physiology
(Karger Available online 1988)
卷期:
Volume 1,
issue 2
页码: 100-105
ISSN:1660-5527
年代: 1988
DOI:10.1159/000210755
出版商: S. Karger AG
关键词: Dermatitis, allergic contact;Dermatitis, irritant;Lipoxygenase inhibitor;Platelet-activating factor antagonist
数据来源: Karger
摘要:
A 5-lipoxygenase inhibitor (5-LPI) and a platelet-activating factor antagonist (PAF-A) were studied in dinitrofluorobenzene (DNFB)-induced allergic and croton-oil-induced irritant murine contact dermatitis. Both inhibitors, at 1 and 5% concentrations, significantly reduced the ear swelling in allergic dermatitis while irritant dermatitis was far less affected. This suggests that 5-lipoxygenase-dependent mediators and PAF are involved in allergic contact dermatitis and that these mediators play only a minor role in irritant dermatitis.
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