Early effects of efferent ductule ligation on the proximal segment of the rat epididymis
作者:
L. Nicander,
D. I. Osman,
L. Pløen,
H. P. Bugge,
K. N. Kvisgaard,
期刊:
International Journal of Andrology
(WILEY Available online 1983)
卷期:
Volume 6,
issue 1
页码: 91-102
ISSN:0105-6263
年代: 1983
DOI:10.1111/j.1365-2605.1983.tb00326.x
出版商: Blackwell Publishing Ltd
关键词: efferent ductule ligation;epididymal degeneration;rat;testicular fluid;apoptosis
数据来源: WILEY
摘要:
The effects on the proximal caput epididymidis of efferent ductule ligation were studied. After 6 h there was a slight increase in autophagocytosis in the initial segment proper (1A). After 12 h this segment showed cell death and cytoplasmic regression and after 24 h large amounts of necrotic cells and focal degeneration in the epithelium, and desquamated cells and débris in the lumen. After 48 h the epithelium was lower, but degeneration less obvious. Segments 1B, 1C and 2 showed marked cell death and cytoplasmic degeneration. This was more evident after 3 days, especially in 1B. After 5 and 7 days some degeneration was still seen, but essentially regional differences had disappeared, leaving a lower, inactive epithelium throughout. Except for an increase in glycogen granules in segment 1C after 48 h, marked focal degeneration always appeared before general cytoplasmic alterations. Sham operation produced no changes. The regression might be caused by the cut supply of androgen binding protein or a growth factor in rete testis fluid
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