ABSTRACT:An index of self‐sufficiency in children with Down's syndrome was developed for use in a study of the process of adaptation in families living in the Greater Manchester area. The children were 6‐14 years old, and living at home. Index scores were based on the mothers’responses to a questionnaire covering their children's personal and domestic functioning and community self‐sufficiency, and were obtained from 111 of the 117 mothers who took part in the study. A wide range of child‐ and family‐related variables were found to be significantly associated with self‐sufficiency scores on a univariate level. Multiple regression analysis was used to identify those variables which best predicted the level of self‐sufficiency achieved. After the child's mental age, the most significant variables were excitability, behaviour problems, the extent the mother used practical means of coping, and the level of social activity experienced by the child. Together, these five variables explained 63% of the variance in self‐sufficiency scores. The dynamics by which such factors may relate to selfsufficiency in children with Down's syndrome are discussed, and intervention aimed at promoting the use of practical ways of coping by par