Effect of Acute Ethanol Intoxication on Primary Haemostasis, Coagulation Factors and Fibrinolytic Activity
作者:
E. Zoucas,
D. Bergqvist,
G. Göransson,
S. Bengmark,
期刊:
European Surgical Research
(Karger Available online 1982)
卷期:
Volume 14,
issue 1
页码: 33-44
ISSN:0014-312X
年代: 1982
DOI:10.1159/000128220
出版商: S. Karger AG
关键词: Ethanol;Liver resection;Mesenteric vessel transection;Coagulation;Fibrinolysis;Platelet aggregation
数据来源: Karger
摘要:
The effect of ethanol intoxication on haemostasis was studied by transection of mesenteric microvessels and liver resection in the rat. Plasma concentrations of alcohol were within the range of those found in ethanol intoxication in man. Bleeding time and blood loss were increased 1 h after ethanol administration, regardless of the utilized technique. A significant positive correlation existed between bleeding time following liver resection and bleeding time after simultaneous transection of a mesenteric arteriole and venule. Coagulation mechanisms, assayed by whole blood clotting time, APT time, one-stage prothrombin time, recalcification time, thrombin time, Owren’s P & P test and determination of plasma factor V and fibrinogen levels, were not significantly changed in ethanol-intoxicated animals. Administration of alcohol did not affect fibrinolytic activity, while it inhibited significantly ADP and collagen-induced platelet aggregation in the ra
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