Wound healing using a collagen matrix: Effect ofDCelectrical stimulation
作者:
Michael G. Dunn,
Charles J. Doillon,
Richard A. Berg,
Robert M. Olson,
Frederick H. Silver,
期刊:
Journal of Biomedical Materials Research
(WILEY Available online 1988)
卷期:
Volume 22,
issue S13
页码: 191-206
ISSN:0021-9304
年代: 1988
DOI:10.1002/jbm.820221310
出版商: John Wiley&Sons, Inc.
数据来源: WILEY
摘要:
AbstractRapid fibroblast ingrowth and collagen deposition occurs in a reconstituted type I collagen matrix that is implanted on fullthickness excised animal dermal wounds. The purpose of this study is to evaluate the effects of direct current stimulation on dermal fibroblast ingrowth using carbon fiber electrodes incorporated into a collagen sponge matrix. Preliminary results suggest that fibroblast ingrowth and collagen fiber alignment are increased in collagen sponges stimulated with direct currents between 20 and 100 μA. Maximum fibroblast ingrowth into the collagen sponge is observed near the cathode at a current of 100 μA. These results suggest that electrical stimulation combined with a collagen matrix may be a method to enhance the healing of chronic dermal wound
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