Medication Outcome in ECT‐Resistant Depression
作者:
Baruch Shapira,
Seth Kindler,
Bernard Lerer,
期刊:
Convulsive Therapy
(OVID Available online 1988)
卷期:
Volume 4,
issue 3
页码: 192-198
ISSN:0749-8055
年代: 1988
出版商: OVID
关键词: Major depression;Electroconvulsive therapy;Tricyclic antidepressants:;Lithium
数据来源: OVID
摘要:
The outcome of antidepressant treatment in 12 cases of electroconvulsive therapy (ECT)-resistant depression is presented. Eight patients had been refractory to a clinically adequate course of ECT (Hamilton Depression Scale improvement <20%) and four were partial responders (improvement 20–49%). All remitted completely on antidepressant medication within 2.2 ± 1.1 (mean ± SD) months of the ECT course. Remission was associated with clomipramine treatment (139 ± 49.7 mg/day) in seven cases and maprotiline (125 mg/day) in one case. Four patients who did not respond to a tricyclic antidepressant alone remitted following supplementation (of clomipramine in 2 cases, clomipramine + haloperidol in 1 case, and imipramine in 1 case) with lithium carbonate. Although a delayed therapeutic response to ECT cannot be excluded, the results suggest that ECT may alter the sensitivity of refractory patients to antidepressant medication.
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