Tocainide and Tinnitus
作者:
Bengt Larsson,
Leif Lyttkens,
Sven-Anders Wästerström,
期刊:
ORL
(Karger Available online 1984)
卷期:
Volume 46,
issue 1
页码: 24-33
ISSN:0301-1569
年代: 1984
DOI:10.1159/000275680
出版商: S. Karger AG
关键词: Tinnitus;Inner ear;Melanin;Tocainide
数据来源: Karger
摘要:
Tocainide, an amine analogue of lidocaine, which can be taken orally, was tested on 9 patients with severe tinnitus. 6 patients responded to the drug. In 4 patients the effect ceased after about 2 weeks despite continuous medication. 2 patients are still on this medication after more than 2 years. The binding of tocainide to melanin was analysed in vitro and in vivo in rats. It was concluded that the effect of tocainide on tinnitus is mediated by a peripheral mechanism possibly related to the accumulation on inner ear melanin.
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