Myocardial dysfunction in septic shock: basic mechanisms and emerging concepts
作者:
Andreas Hoeft,
Douglas Mann,
期刊:
Current Opinion in Anaesthesiology
(OVID Available online 1994)
卷期:
Volume 7,
issue 1
页码: 26-32
ISSN:0952-7907
年代: 1994
出版商: OVID
数据来源: OVID
摘要:
There is growing evidence that myocardial dysfunction in 'septic shock is induced by mediators of the systemic inflammatory respopse syndrome, in particular by cytokines such as tissue necrosis factor-a (TNF-a) and interleukin-1 (IL-1). TNF-a produces an immediate negative inotropic effect by alteration in intracellular calcium homeostasis. Longer term effects of TNF-a and IL-1 may involve increased expression of NO synthase and decreased responsiveness of p-adrenergic stimulation. Most recently, strategies have been formulated to try and inhibit or attenuate toxic effects of TNF-a and IL-1; this has included the use of anti-TNF-a antibodies, soluble receptors for TNF-a, and recombinant IL-1 receptor antagonists.
点击下载:
PDF
(730KB)
返 回