AbstractFollowing a large meal there is a transient and large increase in the metabolic clearance rate of progesterone.1Progesterone receptors do not bind to molecules of progesterone in the presence of adrenalin,2which is released when the blood glucose level is low. While awaiting their first appointment, 84 women with severe premenstrual syndrome (PMS) completed a questionnaire detailing all food and drink consumed on seven consecutive days. The average daytime interval between starch‐containing foods was 7 hours, with an overnight interval averaging 13 ½ hours. This suggested that women with PMS might benefit from shorter food intervals between starch‐containing foods and avoidance of large meals. On receipt of their questionnaires women were advised to follow a three‐hourly starch diet, which was beneficial in 54 per cent with improvement in a further 20 per cent. The diet alone proved effective in 19 per cent, who needed no additional medication for full relief of premenstrual sy