Amdinocillin: Interaction with Other Beta-Lactam Antibiotics for Gram-Negative Bacteria
作者:
Robert H.K. Eng,
Rosita Liu,
Sharon M. Smith,
Edward S. Johnson,
Charles E. Cherubin,
期刊:
Chemotherapy
(Karger Available online 1988)
卷期:
Volume 34,
issue 1
页码: 18-26
ISSN:0009-3157
年代: 1988
DOI:10.1159/000238542
出版商: S. Karger AG
关键词: Amdinocillin;Antibiotic combinations;Antibiotic interaction;Antibiotic synergy;Penicillin-binding proteins
数据来源: Karger
摘要:
Amdinocillin was studied alone and in combination with three other beta-lactam antibiotics (aztreonam, cefoperazone, and ceftriaxone) for activity against gram-negative bacilli. These antibiotic combinations failed to show synergy by the checkerboard double-dilution test or by killing kinetic studies. However, amdinocillin did show additive killing action when combined with the other beta-lactam antibiotics studied. Amdinocillin failed to induce or inhibit beta-lactamase production in species of Enterobacteriaceae, but with Pseudomonas aeruginosa, beta-lactamase production was induced. It is concluded that the activity of amdinocillin alone or in combination with another beta-lactam antibiotic should not be more effective in the treatment of infections by gram-negative bacilli than just using the beta-lactam antibiotic alone at a higher dose.
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