AbstractThere were 30 cases of cylindroma at Ellis Fischel State Cancer Hospital from 1940 to 1969. Of these 30 cases, 22 were seen initially at Ellis Fischel. Fourteen patients died of cylindroma; the average survival from diagnosis to death was 66 months. Reappearance occurred in 20 of the 30 cases, with the interval between the first reappearance of tumore being 32 months. Tumor was located in the major salivary gland in 9 cases, minor salivary gland in 8 cases, and paranasal sinuses in 3 cases. Tumor frequently invaded bone, became fixed to surrounding structures, and not infrequently metastasized widely. Treatment consisted of surgery and/or radiation therapy. Of the 22 cases seen initially at Ellis Fischel, 16 were pure cylindromas, 2 were mixed with mucoepidermoid, 1 was mixed with adenocarcinoma, and 3 were mixed with epidermoid carcinoma. Four patients were cured of their cylindormas, as determined by survival at 10 or more years. All these cures were arrived at through surgical extirpation of the tumor. Radiotherapy and infusion chemotherapy gave good palliation but no cures. Adequacy of margin around the tumor was the single most important factor in cure. It is found that biopsy of the tumor did not alter survival. Patients with parotid tumors did much better than tumors located in other areas. Fixation of the tumor mass did not alter survival and nodal involvement was an ominous sign. The study indicated the way to improve survival was by resecting the tumor re‐resecting until all margins are adequat