The Calcitonin Gene Peptides: Biology and Clinical Relevance
作者:
ZaidiMone,
MoongaBaljit S.,
BevisPeter J. R.,
BascalZainab A.,
BreimerLars H.,
期刊:
Critical Reviews in Clinical Laboratory Sciences
(Taylor Available online 1990)
卷期:
Volume 28,
issue 2
页码: 109-174
ISSN:1040-8363
年代: 1990
DOI:10.3109/10408369009105900
出版商: Taylor&Francis
关键词: calcitonin;amylin;osteoclast;peptide;bone;vasculature
数据来源: Taylor
摘要:
AbstractThe calcitonin/CGRP multigene complex encodes a family of peptides: calcitonin, its C-terminal flanking peptide, katacalcin, and a third novel peptide, calcitonin gene-related peptide (CGRP). The 32-amino acid peptide calcitonin inhibits the osteoclast, thereby conserving skeletal mass during periods of potential calcium lack, such as pregnancy, growth, and lactation. This hormonal role is emphasized by observations that lower circulating calcitonin levels are associated with bone loss and that calcitonin replacement prevents further bone loss. Structurally, CGRP resembles calcitonin and has been implicated in neuromodulation and in the physiological regulation of blood flow. Here we review the molecular genetics, structure, and function of the calcitonin-gene peptides as analyzed in the laboratory and focus on more recent clinical studies relating to disorders and therapeutics.
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