Clonidine and Naltrexone in the Outpatient Treatment of Heroin Withdrawal
作者:
KleberHerbert D.,
TopazianMark,
GaspariJoseph,
RiordanCharles E.,
KostenThomas,
期刊:
The American Journal of Drug and Alcohol Abuse
(Taylor Available online 1987)
卷期:
Volume 13,
issue 1-2
页码: 1-17
ISSN:0095-2990
年代: 1987
DOI:10.3109/00952998709001497
出版商: Taylor&Francis
数据来源: Taylor
摘要:
AbstractClonidine hydrochloride (an alpha-2 adrenergic agonist) and naltrexone hydrochloride (an opioid antagonist), given in combination, provided a safe and effective treatment of abrupt opioid withdrawal over 5 days in an outpatient/day setting. Before starting the clonidine, a naloxone challenge test was used to verify and quantify opioid dependence, and the naloxone challenge test score was then used to determine initial medication doses. Initial naloxone challenge test scores predicted subsequent patient discomfort during the 5-day clonidine-naltrexone protocol. Twelve of 14 (86%) heroin users successfully withdrew from opioids and simultaneously initiated naltrexone maintenance.
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