Identification and characterization of immature thymocytes responsive to T cell growth factor
作者:
Petr Dráber,
Pawel Kisielow,
期刊:
European Journal of Immunology
(WILEY Available online 1981)
卷期:
Volume 11,
issue 1
页码: 1-7
ISSN:0014-2980
年代: 1981
DOI:10.1002/eji.1830110102
出版商: WILEY‐VCH Verlag GmbH
数据来源: WILEY
摘要:
AbstractThe surface antigenic phenotype of peanut lectin agglutinin (PNA)‐separated, high‐density (“immature”) thymocytes which are the target for the T cell growth factor (TCGF) enabling this otherwise unresponsive cell population to mount a strong proliferative response to concanavalin A (Con A) has been studied. The results obtained indicate that (a) the major population of cells bearing the typical phenotype of immature thymocytes,i.e.low content of H‐2, high content of Thy‐1, TL, Lyt‐1 and Lyt‐2 antigens, is unable to respond to Con A in the presence of TCGF, and (b) that the responsive population constitutes a minor fraction (about 15%) of PNA+, high‐density thymocytes with surface antigenic phenotypes similar to those of mature T cells,i.e.high content of H‐2, low content of Thy‐1 and differentiated expression of Lyt antigens. Such a unique combination of properties and the presence of TL antigen on some members of the responding population suggest that it contains cells at intermediate stage(s) of differentiation between immature t
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