Morphological Platelet Anomalies in Thrombotic Thrombocytopenic Purpura
作者:
Dan Aderka,
Meir Djaldetti,
Yehuda Shoenfeld,
Matti Shaklai,
Moshe Santo,
Shlomo Berliner,
Abraham Weinberger,
Jack Pinkhas,
期刊:
Acta Haematologica
(Karger Available online 1982)
卷期:
Volume 67,
issue 2
页码: 119-123
ISSN:0001-5792
年代: 1982
DOI:10.1159/000207037
出版商: S. Karger AG
关键词: Thrombotic thrombocytopenic purpura;Ultrastructure of platelets
数据来源: Karger
摘要:
A patient with thrombotic thrombocytopenic purpura was treated with 8 U of fresh frozen plasma, resulting in a rapid improvement in her condition and subsequently followed by a prolonged clinical remission. The transmission and scanning electron microscopic examinations of the platelets performed before treatment demonstrated marked anomalies of the platelet morphology, namely, an increased number of abnormally elongated pseudopods with terminal knobs, a decreased number of platelet granules and excess of glycogen and marked anisocytosis, These anomalies remained unchanged when reexamined 2 months after the achievement of the clinical remission. The question whether these platelet abnormalities are an integral part of thrombotic thrombocytopenic purpura and play a role in its pathogenesis, is raised.
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