Isolation and Some Characteristics of Urokinase Inhibitors Isolated from Pig Leucocytes
作者:
M. Kopitar,
期刊:
Pathophysiology of Haemostasis and Thrombosis
(Karger Available online 1981)
卷期:
Volume 10,
issue 4
页码: 215-232
ISSN:1424-8832
年代: 1981
DOI:10.1159/000214406
出版商: S. Karger AG
关键词: Leucocyte intracellular inhibitors of urokinase;Isolation procedure;Biochemical characteristics
数据来源: Karger
摘要:
Two inhibitors of urokinase were isolated from the extracts of the nuclei of peripheral pig leucocytes, by ion exchange chromatography and by gel filtration on Sephadex G-100 and G-150. Only the inhibitor with the higher molecular weight was isolated in the homogenous form, in a single polypeptide chain with molecular weight of 68,000, designated Inhibitor-3. This inhibitor has an isoelectric point from 4.4 to 4.5 and is stable in buffer solutions from pH 3 to 8, and belongs to the type of so-called fast reacting inhibitors.
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