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A Neuroendocrine View of ECT

 

作者: Max Fink,   Charles Nemeroff,  

 

期刊: Convulsive Therapy  （OVID Available online 1989）
卷期: Volume 5, issue 3  

页码: 296-304

 

ISSN:0749-8055

 

年代: 1989

 

出版商: OVID

 

关键词: Electroconvulsive therapy;Depressive disorders: therapy;Seizures: physiopathology;Thyrotropin-releasing hormone;Endorphins;Hormones: metabolism

 

数据来源: OVID

 

摘要:

A neuroendocrine hypothesis to explain the clinical activity of convulsive therapy is described. The hypothesis is based on the diabetes/insulin model and suggests that hypothalamic dysfunction with an insufficiency of a mood-maintaining peptide is the basis for affective disorders. Repeated seizures enhance the production and release of the hypothalamic peptideantidepressin-the active principle that relieves both neuroendocrine and behavioral abnormalities.

 

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