Detection of Sclerosis-Inducing Glycosaminoglycan in the Skin of an Amine-Induced Experimental Skin Sclerosis
作者:
Hidekazu Ishikawa,
Akio Yamakage,
Masato Kitabatake,
Hiroshi Katayama,
Yoshio Saito,
期刊:
Dermatology
(Karger Available online 1980)
卷期:
Volume 161,
issue 3
页码: 145-151
ISSN:1018-8665
年代: 1980
DOI:10.1159/000250350
出版商: S. Karger AG
关键词: Glycosaminoglycan;Systemic scleroderma;Experimental skin sclerosis;Synthetic amine
数据来源: Karger
摘要:
The presence of sclerosis-inducing glycosaminoglycan in the skin was confirmed in an experimental skin sclerosis induced by a chemical compound. An experimental skin sclerosis was first produced in the mouse with bis(4-amino-3-methylcyclohexyl)methane. Out of glycosaminoglycans isolated from the slightly changed skin of this experimental skin sclerosis, the one having a heparan sulfate-like structure was able to again induce sclerotic skin changes in another mouse. The chemical composition of this sclerosis-inducing glycosaminoglycan was somewhat similar to that of the scleroderma-inducing glycosaminoglycan isolated previously from the urine of patients with systemic scleroderma.
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