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Topical Vitamin A Acid (Airol®) and Systemic Oxytetracycline in the Treatment of Acne Vulgaris

 

作者: Jørgen V. Christiansen,   Ejnar Gadborg,   Knud Ludvigsen,   Carl H. Konstmann Meier,   Asger Nørholm,   P.E. Osmundsen,   Daniel Pedersen,   Kaj A. Rasmussen,   Henry Reiter,   Flemming Reymann,   Niels Rosman,   Bent Sylvest,   Paul Unna,   Robert Wehnert,   Bent Aastrup,   Bjørn Andersen,   Per Holm,  

 

期刊: Dermatology  （Karger Available online 1974）
卷期: Volume 149, issue 2  

页码: 121-128

 

ISSN:1018-8665

 

年代: 1974

 

DOI:10.1159/000251498

 

出版商: S. Karger AG

 

关键词: Acne;Tretinoin;Oxytetracycline;Controlled Trial

 

数据来源: Karger

 

摘要:

A double-blind, controlled multi-centre trial with 238 patients was employed to study the relative merits of three treatment schedules in acne vulgaris. Schedule A consisted of oral oxytetracycline and topical vitamin A acid cream (0.05%), schedule B of oral oxytetracycline alone, and schedule C of vitamin A acid alone. Large and statistically significant reductions occurred in the number of come dones, papules and pustules during 8 weeks of therapy, which could be attributed neitherto placebo effects nor to natural history of the disease.

 

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