NEUROPATHOLOGICAL DEFINITION OF ALZHEIMER DISEASE: MULTIVARIATE ANALYSES IN THE MORPHOMETRIC DISTINCTION BETWEEN ALZHEIMER DEMENTIA AND NORMAL AGING
作者:
Melvyn Ball,
Sharon Griffin-Brooks,
JoAnn MacGregor,
Béla Nagy,
Ester Ojalvo-Rose,
Peter Fewster,
期刊:
Alzheimer Disease and Associated Disorders
(OVID Available online 1988)
卷期:
Volume 2,
issue 1
页码: 29-37
ISSN:0893-0341
年代: 1988
出版商: OVID
关键词: Alzheimer Disease;Quantitative Morphometry;Multivariate Analysis;Hippocampus
数据来源: OVID
摘要:
Although establishing that a patient is suffering from dementia of the Alzheimer type initially reflects a clinician's opinion, neuropathological study is for the present the most definitive examination to confirm the clinical diagnosis of Alzheimer disease. We review several comprehensive publications attempting on a quantitative basis to differentiate the changes occurring with normal aging of the human brain from those indicative of Alzheimer disease. New morphometric data on 5 histopathological lesions in the mesial temporal cortex of 42 subjects indicate that, when multivariate analyses are performed on such microscopic information, a diagnostic prediction about the brain of any unknown individual should indeed be possible with a statistically calculated degree of certainty
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