Lack of association between the apolipoprotein B gene 3‘ hypervariable region alleles and coronary artery disease in Finnish patients with angiographically documented coronary artery disease
作者:
T. HELIÖ,
A. PALOTIE,
K. J. TÖTTERMAN,
J. OTT,
R. KAUPPINEN‐MÄKELIN,
M. J. TIKKANEN,
期刊:
Journal of Internal Medicine
(WILEY Available online 1992)
卷期:
Volume 231,
issue 1
页码: 49-57
ISSN:0954-6820
年代: 1992
DOI:10.1111/j.1365-2796.1992.tb00498.x
出版商: Blackwell Publishing Ltd
关键词: apolipoprotein B;coronary artery disease;hyperlipidaemia;VNTR
数据来源: WILEY
摘要:
Abstract.Previous studies have suggested that some apolipoprotein B (apoB) 3′ variable number of tandem repeats (3′VNTR) locus alleles are associated with coronary artery disease (CAD). We examined the possible association between the apoB 3′VNTR alleles and CAD in 387 Finnish subjects. Using the polymerase chain reaction and polyacrylamide gel electrophoresis, the 3′VNTR genotype was determined in 187 individuals with severe CAD confirmed by coronary angiography (patients), in 121 individuals with normal coronary angiograms (controls), and in 79 apparently healthy subjects (normals). In contrast to previous reports from other populations, the larger apoB 3′VNTR alleles were not significantly more frequent among CAD patients than among controls or normals. In addition, there was no significant association between the 3′VNTR alleles and serum lipid levels in this Finnish
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