This article offers a unique perspective on health promotion and the La Salle University Neighborhood Nursing Center, located in an urban area of Philadelphia. Its authors have been and continue to be intimately involved in the nursing center movement in the greater Philadelphia area and present this model as an exemplar of primary health care and health promotion in a changing urban community. Health promotion at the individual and aggregate level is described using the specific examples of immunization, lead poisoning prevention, and cancer awareness and screening.