A second nonrandom translocation, der(16)t(1;16)(q21;q13), in Ewing sarcoma and peripheral neuroectodermal tumor
作者:
E.C. Douglass,
S.T. Rowe,
M. Valentine,
D. Parham,
W.H. Meyer,
E.I. Thompson,
期刊:
Cytogenetic and Genome Research
(Karger Available online 1990)
卷期:
Volume 53,
issue 2-3
页码: 87-90
ISSN:1424-8581
年代: 1990
DOI:10.1159/000132901
出版商: S. Karger AG
数据来源: Karger
摘要:
The majority of Ewing sarcomas and peripheral neuroectodermal tumors (PNET) that have been karyotyped contain a specific translocation, t(11;22)(q23;q11). We report here a second nonrandom translocation, der( 16)t(1; 16)(q21;q13), in 2 of 20 cases of Ewing sarcoma (seven previously unreported) and 2 of 7 cases of PNET (all previously unreported). All cases with this translocation also contained the t(l 1;22). Comparison of C-banding patterns in tumor and peripheral lymphocyte karyotypes in one case indicated that the likely breakpoints were lq21 and 16q13. The presence of this translocation in cell lines will enable further investigation of the molecular events important in the pathogenesis of Ewing sarcoma and PNET.
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