Incidence, Prognostic Significance and Therapeutic Modalities of Central Nervous System Involvement in Multiple Myeloma
作者:
B. Brenner,
A. Carter,
I. Tatarsky,
J. Gruszkiewicz,
E. Peyser,
期刊:
Acta Haematologica
(Karger Available online 1982)
卷期:
Volume 68,
issue 2
页码: 77-83
ISSN:0001-5792
年代: 1982
DOI:10.1159/000206956
出版商: S. Karger AG
关键词: Intracranial plasmacytoma;Spinal cord compression;Multiple myeloma
数据来源: Karger
摘要:
In 114 patients with systemic malignant gammopathies followed during a 10-year period in the hematology clinic of the Rambam Medical Center, 23 episodes of CNS involvement were recorded. 19 cases with spinal cord compression and 4 cases of intracranial plasmacytomas. Early diagnosis followed by prompt laminectomy and subsequent radiotherapy resulted in complete recovery in 50% and partial improvement in 30% of the patients with spinal cord involvement. In good responders. overall survival was not affected by the neurological complication. In the 4 patients with intracranial involvement, external plasmacytomas of the skull preceded the neurological symptoms. 3 of them were diagnosed late, which led to delay and failure of accurate treatment. Only 1 patient was immediately operated and continued to be well for the past 2 years.
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