Hepatocyte changes following selenium accumulation in a freshwater teleost
作者:
E. Sorensen,
T. Bauer,
C. Harlan,
A. Pradzynski,
J. Bell,
期刊:
The American Journal of Forensic Medicine and Pathology
(OVID Available online 1983)
卷期:
Volume 4,
issue 1
页码: 25-32
ISSN:0195-7910
年代: 1983
出版商: OVID
数据来源: OVID
摘要:
This report provides morphological and analytical data for a group of green sunfish collected from an area relatively free of metals and a second group of the same species collected from a lake into which selenium had been discharged. Neutron activation data of livers (and kidneys) collected from these fish show an average of about 11 ppm selenium (fresh weight) for both organs; other metals were not detected in the liver (or kidneys) of these fish. Ultrastructural examination of livers from fish of this group showed focal necrosis, areas of granular cytoplasm, fatty infiltration, increased numbers of Kupffer cells, and disorganized liver architecture—compared with those of controls. The presence of massive levels of selenium in the liver and concomitant hepatocyte changes suggests a causal relationship between these phenomena.
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