Sequential Development of Waldenström’s Macroglobulinemia and Gamma-1-Heavy Chain Disease in a Single Patient
作者:
T. Ockhuizen,
J.F. Jilderda,
T. Cazemier,
期刊:
Acta Haematologica
(Karger Available online 1984)
卷期:
Volume 71,
issue 1
页码: 53-59
ISSN:0001-5792
年代: 1984
DOI:10.1159/000206510
出版商: S. Karger AG
关键词: Asynchronous development;γ-Heavy chain disease;Waldenström’s macroglobulinemia
数据来源: Karger
摘要:
The present paper deals with the rare phenomenon of the sequential development of Waldenström’s macroglobulinemia (WM) and γ1 heavy chain disease (γ1-HCD) in a single patient. The coexistence of both monoclonal proteins lasted for more than 9 years. Serial determinations were made of serum levels of IgM, IgA, intact IgG, and the γ-HCD protein. Immunofluorescent studies of a bone marrow aspirate confirmed the diagnosis of an IgM(κ) monoclonal gammopathy and also showed cells which were thought to synthesize the γ-HCD protein. The molecular weight of the γ-HCD protein was 60,000 in the dimeric form. It is concluded that the original IgM(eκ) monoclonal gammopathy predisposed the patient for a second lymphoproliferative disorder (the γ-HCD) and that both monoclonal proteins are immunogenetically
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