首页   按字顺浏览 期刊浏览 卷期浏览 Certain Neuroleptics Reduce Bone Mineralization in Schizophrenic Patients
Certain Neuroleptics Reduce Bone Mineralization in Schizophrenic Patients

 

作者: T. Higuchi,   T. Komoda,   M. Sugishita,   J. Yamazaki,   M. Miura,   Y. Sakagishi,   T. Yamauchi,  

 

期刊: Neuropsychobiology  （Karger Available online 1987）
卷期: Volume 18, issue 4  

页码: 185-188

 

ISSN:0302-282X

 

年代: 1987

 

DOI:10.1159/000118415

 

出版商: S. Karger AG

 

关键词: Urinary hydroxyproline;25(OH)D3;l;25(OH)2D3;Bone mineralization;Neuroleptics;Schizophrenia;Urinary calcium;Urinary alkaline phosphatase activity

 

数据来源: Karger

 

摘要:

A significant increase of urinary Ca and hydroxyproline levels and a decrease of urinary alkaline phosphatase activity were found in 12 schizophrenic patients receiving certain neuroleptic drugs. In these patients, the levels of active metabolites of vitamin D3 were decreased, while the levels of midmolecule parathyroid hormone were within the normal range, except for 2 cases. These results suggest that certain neuroleptics induce the increased urinary Ca excretion through suppression of active vitamin D3 formation and that chronic treatment with certain neuroleptics may induce abnormal bone mineralization.

 

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