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Thalidomide Can Be Either Agonistic or Antagonistic to LPS Evoked Synthesis of Tnf-αby Mononuclear Cells

 

作者: ShannonEdward J.,   SandovalFelipe,  

 

期刊: Immunopharmacology and Immunotoxicology  (Taylor Available online 1996)
卷期: Volume 18, issue 1  

页码: 59-72

 

ISSN:0892-3973

 

年代: 1996

 

DOI:10.3109/08923979609007110

 

出版商: Taylor&Francis

 

数据来源: Taylor

 

摘要:

AbstractThe effect if thalidomide on tumor necrosis factor alpha (TNF-α) produced in vitro by lipopolysaccharide (LPS) stimulated human cells was investigated. In cultures of LPS stimulated human mononuclear cells enriched for adherent cells and in cultures of LPS stimulated human monocytes of the cell line-THP-1, thalidomide ehanced the synthesis of TNF-α. When cultures of un-fractionated peripheral blood mononuclear cells were stimulated with LPS, thalidomide decreased the synthesis of TNF-α. Depending on the type of cells stimulated with LPS in vitro, thalidomide, at concentrations achieved in vivo, can either enhance or suppress the synthesis of TNF-α

 

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