Phase II Evaluation of Carboplatin in Advanced Esophageal Carcinoma
作者:
W. Queißer,
P. Preusser,
K.B. Mross,
D. Fritze,
K. Rieche,
J.-H. Beyer,
W. Achterrath,
L. Edler,
期刊:
Onkologie
(Karger Available online 1990)
卷期:
Volume 13,
issue 3
页码: 190-193
ISSN:0378-584X
年代: 1990
DOI:10.1159/000216756
出版商: S. Karger GmbH
关键词: Phase II trial;Carboplatin;Dose escalation;Esophageal carcinoma
数据来源: Karger
摘要:
Eighteen patients with advanced squamous cell carcinoma of the esophagus without prior chemotherapy were treated with carboplatin. Based on experimental data a split dose of carboplatin of 130 mg/m2 given on days 1, 3 and 5 was administered. In cases showing no WBC and platelet suppression, an escalated dose of 160 mg/m2 was proposed. Out of 18 evaluable patients no complete and partial responses were observed and there were only 5 patients with stable disease (27.8%) lasting 2–7 months. Therefore, carboplatin in the regimen used shows no meaningful antitumor activity in patients with advanced esophageal carcinoma. The escalated dose (mean 107–123% of the starting dose) was well tolerated and was followed by only minor gastrointestinal and hematological toxicity. Therefore, this regimen can be recommended for future tri
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