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Effect of Phenobarbitone on Bile Flow and Bilirubin Metabolism in Man and the Rat

 

作者: J.D. Maxwell,   John Hunter,   D.A. Stewart,   M. Carrella,   Roger Williams,  

 

期刊: Digestion  （Karger Available online 1973）
卷期: Volume 9, issue 2  

页码: 138-148

 

ISSN:0012-2823

 

年代: 1973

 

DOI:10.1159/000197440

 

出版商: S. Karger AG

 

关键词: Bile;Bilirubin;Cytochrome P 450;Enzyme induction;Gunn rats;Hyperbilirubinaemia;hereditary;Jaundice;Liver function test;Phenobarbital;Rats.

 

数据来源: Karger

 

摘要:

Phenobarbitone in doses causing significant increase in bile flow had no effect on plasma bilirubin levels in the rat, nor on biliary excretion of endogenous bilirubin. In patients with Gilbert’s syndrome small doses of phenobarbitone lowered bilirubin levels without any accompanying change in BSP Tm. In these patients and in normal subjects the fall in plasma bilirubin after enzyme-inducing drugs was correlated with changes in the activity of hepatic enzymes. These studies suggest that species variations in response to the effects of phenobarbitone on bilirubin metabolism may be importa

 

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