Chromosomal localization of human lactotransferrin gene (LTF) by in situ hybridization
作者:
J.L. McCombs,
C.T. Teng,
B.T. Pentecost,
V.L. Magnuson,
C.M. Moore,
J.R. McGilL,
期刊:
Cytogenetic and Genome Research
(Karger Available online 1988)
卷期:
Volume 47,
issue 1-2
页码: 16-17
ISSN:1424-8581
年代: 1988
DOI:10.1159/000132496
出版商: S. Karger AG
数据来源: Karger
摘要:
Lactotransferrin (LTF) is an important member of the transferrin family of proteins. These proteins play an essential role in the transport of iron in extracellular fluid (Aisen and Lis-towsky, 1980). Southern blot analysis of mouse-human somatic cell hybrids have localized the LTF gene to region q21→qter of human chromosome 3 (Teng et al., unpublished data). Using the same full-length mouse cDNA probe (2.2 kb), the LTF gene was mapped to human chromosomal bands 3q21→q23 by in situ hybridization. The sublocalization of the LTF gene to 3q21→q23 is in the region of human chromosome 3 where the gene loci of transferrin and transferrin receptor have been localized (Yang et al., 1984; van de Rijn et al.,
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