Chronic inflammatory demyelinating polyradiculoneuropathy is an immune-mediated disorder which usually responds to treatment Accurate diagnosis is essential and depends on the clinician's ability to synthesize a variety of clinical, electrodiagnostic, and laboratory data. The prognosis is generally good, This review summarizes the pathogenesis, clinical presentation, evaluation, treatment, and prognosis of adults and children with CIDP with practical guidelines for selection of the most appropriate diagnostic tests and treatment modalities.