首页   按字顺浏览 期刊浏览 卷期浏览 EFFECTS OF ADRENALECTOMY AND ANTIGENIC STIMULATION ON SPLEEN WEIGHT IN MICE
EFFECTS OF ADRENALECTOMY AND ANTIGENIC STIMULATION ON SPLEEN WEIGHT IN MICE

 

作者: J David Kieffer,   Melvin Ketchel,  

 

期刊: Transplantation  (OVID Available online 1971)
卷期: Volume 11, issue 1  

页码: 45-49

 

ISSN:0041-1337

 

年代: 1971

 

出版商: OVID

 

数据来源: OVID

 

摘要:

SUMMARYAdult, nonirradiated C57BL/6J {H-2bfemale mice do not show splenic enlargement following the injection of allogeneic (H-2k) spleen cells. Adrenalectomized, noninjected controls show splenic enlargement at 7, 14, and 21 days after surgery. When adrenalectomized mice are injected with allogeneic spleen cells, the spleens do not enlarge by the 7th day but, by the 14th day, splenic enlargement exceeds that seen in noninjected, adrenalectomized controls. By the 21st day, the spleens, although still enlarged, do not exceed in weight those of the noninjected adrenalectomized controls. Both of these effects —splenic enlargement following adrenalectomy and modification of this enlargement by injection of allogeneic cells—are abolished by injection of cortisone acetate. It is suggested that adrenalectomy may modify the host-versus-graft reaction of mice.

 

点击下载:  PDF (377KB)



返 回