Autografts and homografts were performed in normal and hypervitaminotic A rabbits. In normal animals successful “take” and rejection, respectively, followed their usual course. Autografts and homografts in hypervitaminotic A rabbits were rejected by a peculiar type of reaction grossly reminiscent of the “white graft”. The significant histological findings were lack of adherence between graft and host tissues and paucity of blood vessels in the granulation tissue of the graft bed. The mechanisms(s) underlying autograft rejection in hypervitaminotic A rabbits is unknown. Some effects of vitamin A and their possible relationship to wound healing are discussed. It is presumed that profound metabolic alterations caused by vitamin A overdosage are responsible for the particular phenomenon described.