Studies on thein vitroDevelopment of Drug Resistance of Proteeae to Sulfonamides, Trimethoprim and Combinations of a Sulfonamide and Trimethoprim
作者:
E. Grunberg,
G. Beskid,
期刊:
Chemotherapy
(Karger Available online 1977)
卷期:
Volume 23,
issue 5
页码: 309-313
ISSN:0009-3157
年代: 1977
DOI:10.1159/000222000
出版商: S. Karger AG
关键词: Proteeae;In vitroresistance;Sulfonamides;Trimethoprim
数据来源: Karger
摘要:
A strain of Proteus mirabilis repeatedly subcultured in the presence of a combination of sulfisoxazole and 0.4 μg/ml of trimethoprim and a strain of P. vulgaris subcultured in the presence of sulfamethoxazole and trimethoprim combined in a 5:1 ratio gradually developed resistance to the combinations. However, the level of resistance developed by the organisms exposed to the combination was always appreciably lower than the level of resistance developed by the same strains exposed to either the sulfonamide or trimethoprim alone.
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