A controlled trial for evaluating two live attenuated mumps‐measles vaccines (Urabe Am 9‐Schwarz and Jeryl Lynn‐Moraten) in young children
作者:
Therese Popow‐Kraupp,
Michael Kundi,
Franz Ambrosch,
Hanns Vanura,
Christian Kunz,
期刊:
Journal of Medical Virology
(WILEY Available online 1986)
卷期:
Volume 18,
issue 1
页码: 69-79
ISSN:0146-6615
年代: 1986
DOI:10.1002/jmv.1890180109
出版商: Wiley Subscription Services, Inc., A Wiley Company
关键词: live attenuated measles‐mumps vaccines;seroconversion rate;ELISA
数据来源: WILEY
摘要:
AbstractA prospective, randomised clinical trial was conducted to evaluate the efficacy of two live attenuated mumps‐measles vaccines, the Urabe Am 9‐Schwarz and the Jeryl Lynn‐Moraten vaccine, in 400 young children aged 9 months‐4.5 years (median 13.4 months). Antibody responses to both vaccine components were measured by the enzyme‐linked immunosorbent assay (ELISA); 96.9% of the seronegative children who received the Urabe Am 9‐Schwarz vaccine showed satisfactory mumps antibody responses compared to 90% of the Jeryl Lynn‐Moraten vaccine recipients (P<.01). Similar proportions of both groups, 98.5% and 96.8%, respectively, developed measles virus specific antibodies. Both vaccines were equally well tolerated and clinical
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