In a prospective, population‐based study, 31 patients with pure granulocytopenia lasting longer than six months were followed‐up for up to 7.3 years after diagnosis. Their ages at diagnosis were 0.3–15.5 (median 0.9) years; 17 of the patients were less than 1 year of age. The lowest granulocyte count measured was 0.00–0.60 (median 0.03) × 109/l. During the granulocytopenia, 12 patients suffered from repeated infections but none was life‐threatening. In 21 patients, the granulocyte count normalized spontaneously within 0.5–5.5 (median 1.1) years: the other 10 remain granulocytopenic after follow‐up for 2.5–7.3 (median 3.7) years. We conclude that selective granulocytopcnia, if associated with unimpaired myelopoiesis, is a benign disorder in children and does not. even if prolonged, significantly incrcase thc risk of s