ABSTRACTAn important approach to the treatment of auto‐immune diseases is the selective removal of specifically pathogenic antibodies from the blood. This study reports the effectiveness of using DNA‐combined immuno‐absorbent matrixes for the removal of anti‐DNA antibodiesin vitro. Sera obtained from patients with Systemic Lupus Erythematosus (SLE) were used, as the pathogenesis of SLE is partially mediated by antibodies against DNA (1). A series of DNA‐combined immuno‐absorbent matrices was prepared using several different approaches, and the adsorption of anti‐DNA antibodies from the SLE sera was investigated on these matrices. A comparison was then made between these matrices and commercially available adsorbents with respect to their adsorbing abilities and their stability in sera. Readings of the following were also made before and after the reaction; pH, albumin, globulin, CH50, compliments C5, C4, C5, DNA, DNA and anti‐DNA antibodies complex ratios. Of the adsorbents investigated, the newly prepared immuno‐adsorbent matrix of DNA, glow discharge treated DNA‐PVA on cotton gauze, proved to be the most effective in reducing the anti‐DNA antibodies and immune complex levels specifically, while remaining relatively