The role of hepatic lipase in lipoprotein metabolism and atherosclerosis
作者:
Silvia Santamarina-Fojo,
Changting Haudenschild,
Marcelo Amar,
期刊:
Current Opinion in Lipidology
(OVID Available online 1998)
卷期:
Volume 9,
issue 3
页码: 211-219
ISSN:0957-9672
年代: 1998
出版商: OVID
数据来源: OVID
摘要:
In addition to its traditional role in the hydrolysis of lipoprotein triglycerides and phospholipids, recent studies have implicated hepatic lipase in other aspects of cellular lipid and/or lipoprotein metabolism and atherosclerosis. Hepatic lipase may serve as a ligand that mediates the interaction of lipoproteins to cell surface receptors and/or proteoglycans as well as modulating aortic lesion development in different animal models. Over the past several years significant advances have been made in our understanding of new, alternative mechanisms by which hepatic lipase may modulate lipoprotein metabolism and the development of atherosclerosisin vivo. Curr Opin Lipidol 9:211–219. © 1998 Lippincott–Raven Publishers
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