Two articles in the last issue of The Endocrinologist explored the therapeutic benefits of estrogen replacement therapy in the postmenopausal years. The article by Speroff supported the use of estrogens to prevent heart attack, and the article by Raisz supported their use to moderate the accelerated demoralization of the skeleton that is characteristic of the menopause and its aftermath. The articles, in sum, made a strong case for the uniform use of estrogen replacement therapy in menopausal women. To put this impression into the perspective of a busy practice that is weighted toward this population, 1 have asked Dr. Howard Zacur, Professor of Obstetrics and Gynecology at the Johns Hopkins University Medical School, for his comments, (ed.)